Transcription Factor 7-Like-2 (<b><i>TCF7L2</i></b>) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus
نویسندگان
چکیده
منابع مشابه
transcription factor 7-like 2 polymorphism and context-specific risk of metabolic syndrome, type 2 diabetes, and dyslipidemia
background: the transcription factor 7-like 2 gene (tcf7l2) is an element of the wnt signaling pathway. there is lack of evidence if tcf7l2 has a functional role in lipid metabolism and regulation of the components constitutes the metabolic syndrome (metsyn).the aims of this study were to evaluate whether the risk allele of tcf7l2 gene polymorphism is associated with dyslipidemia and metsyn. ma...
متن کاملAssociation of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects.
OBJECTIVE To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. SUBJECTS AND METHODS The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil. R...
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BACKGROUND Transcription factor 7-like 2 (TCF7L2) is a transcription factor in the Wnt signaling pathway. High levels of TCF7L2 have been reported in most human tissues, including the heart, lung, brain, liver, kidney, placenta, adipose tissues, and pancreatic β-cells. The purpose of this study was to assess the association between TCF7L2 polymorphisms (rs12255372 and rs7903146) and type 2 diab...
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Background: Sexual dysfunction (SD) is one of the important problems in diabetic patients.The present study aimed to determine the prevalence of sexual problems in Iranian women with type 2 diabetes mellitus. Methods: A cross-sectional study was conducted among type 2 diabetic women who visited two outpatient endocrine clinics, namely Imam Hospital and Tuba clinic (Sari, Iran) in 2012. Patients...
متن کاملTranscription factor 7-like 2 polymorphism and context-specific risk of metabolic syndrome, type 2 diabetes, and dyslipidemia
BACKGROUND The transcription factor 7-like 2 gene (TCF7L2) is an element of the Wnt signaling pathway. There is lack of evidence if TCF7L2 has a functional role in lipid metabolism and regulation of the components constitutes the metabolic syndrome (MetSyn). The aims of this study were to evaluate whether the risk allele of TCF7L2 gene polymorphism is associated with dyslipidemia and MetSyn. ...
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ژورنال
عنوان ژورنال: Dubai Diabetes and Endocrinology Journal
سال: 2020
ISSN: 2673-1797,2673-1738
DOI: 10.1159/000509756